Despite the title, very little on-screen time was spent trying to knock off the old lady. Nor was there any allusion to the usual mean of the term ladykiller. There were some funny moments and the quirky characters were fun. The acting was heavily stylized (which I've also seen in a few of the Coen brothers' other films: The Hudsucker Proxy and Raising Arizona—and I suspect that is the case with many other of their movies). There were too many shots of the old, bow-legged lady shuffling down the street. These could've been left out without disrupting the film or compromising it's "artistic integrity" Ultimately this wasn't that great of a movie. Nevertheless, I'm curious to see the original 1955 version which, in addition to Sir Alec Guinness also featured Peter Sellers.
DISCLAIMER: I watched this film as edited for television. I have not seen the original R-rated version and cannot comment on its appropriateness.
 See http://en.wikipedia.org/wiki/Ealing Comedies.
 i.e. "An attractive, charming man who habitually seduces women." Oxford English Dictionary, ladykiller, n., def. 1.
 Such characterization is particularly suited to J. K. Simmons.
 For more info, I suggest you consult the reviews at http://www.kids-in-mind.com/l/ladykillers.htm and http://www.screenit.com/movies/2004/the ladykillers.html.